5AAG
Aurora A kinase bound to an imidazopyridine inhibitor (14b)
Summary for 5AAG
Entry DOI | 10.2210/pdb5aag/pdb |
Related | 5AAD 5AAE 5AAF |
Descriptor | AURORA KINASE A, [3-[[4-[6-chloranyl-2-(1,3-dimethylpyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]pyrazol-1-yl]methyl]phenyl]-(4-methylpiperazin-1-yl)methanone (2 entities in total) |
Functional Keywords | transferase, aurora-a, imidazopyridine, aurora kinase, inhibitor |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: O14965 |
Total number of polymer chains | 1 |
Total formula weight | 33414.68 |
Authors | McIntyre, P.J.,Bayliss, R. (deposition date: 2015-07-24, release date: 2015-09-02, Last modification date: 2024-01-10) |
Primary citation | Bavetsias, V.,Perez-Fuertes, Y.,Mcintyre, P.J.,Atrash, B.,Kosmopoulou, M.,O'Fee, L.,Burke, R.,Sun, C.,Faisal, A.,Bush, K.,Avery, S.,Henley, A.,Raynaud, F.I.,Linardopoulos, S.,Bayliss, R.,Blagg, J. 7-(Pyrazol-4-Yl)-3H-Imidazo[4,5-B]Pyridine-Based Derivatives for Kinase Inhibition: Co-Crystallisation Studies with Aurora-A Reveal Distinct Differences in the Orientation of the Pyrazole N1-Substituent. Bioorg.Med.Chem.Lett., 25:4203-, 2015 Cited by PubMed: 26296477DOI: 10.1016/J.BMCL.2015.08.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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