5AAF

Aurora A kinase bound to an imidazopyridine inhibitor (14a)

5AAF の概要

• エントリーDOI: 10.2210/pdb5aaf/pdb
• 関連するPDBエントリー: 5AAD 5AAE 5AAG
• 分子名称: AURORA KINASE A, 3-((4-(6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl)-1H-pyrazol-1-yl)methyl)-N,N-dimethylbenzamide (2 entities in total)
• 機能のキーワード: transferase, aurora-a, imidazopyridine, aurora kinase, inhibitor
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: O14965
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33359.60

構造登録者

McIntyre, P.J.,Bayliss, R. (登録日: 2015-07-24, 公開日: 2015-09-02, 最終更新日: 2024-01-10)

• 主引用文献: Bavetsias, V.,Perez-Fuertes, Y.,Mcintyre, P.J.,Atrash, B.,Kosmopoulou, M.,O'Fee, L.,Burke, R.,Sun, C.,Faisal, A.,Bush, K.,Avery, S.,Henley, A.,Raynaud, F.I.,Linardopoulos, S.,Bayliss, R.,Blagg, J.; 7-(Pyrazol-4-Yl)-3H-Imidazo[4,5-B]Pyridine-Based Derivatives for Kinase Inhibition: Co-Crystallisation Studies with Aurora-A Reveal Distinct Differences in the Orientation of the Pyrazole N1-Substituent.; Bioorg.Med.Chem.Lett., 25:4203-, 2015; PubMed: 26296477; DOI: 10.1016/J.BMCL.2015.08.003

実験手法

X-RAY DIFFRACTION (2.78 Å)