5AAF

Aurora A kinase bound to an imidazopyridine inhibitor (14a)

Summary for 5AAF

Entry DOI	10.2210/pdb5aaf/pdb
Related	5AAD 5AAE 5AAG
Descriptor	AURORA KINASE A, 3-((4-(6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl)-1H-pyrazol-1-yl)methyl)-N,N-dimethylbenzamide (2 entities in total)
Functional Keywords	transferase, aurora-a, imidazopyridine, aurora kinase, inhibitor
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: O14965
Total number of polymer chains	1
Total formula weight	33359.60
Authors	McIntyre, P.J.,Bayliss, R. (deposition date: 2015-07-24, release date: 2015-09-02, Last modification date: 2024-01-10)
Primary citation	Bavetsias, V.,Perez-Fuertes, Y.,Mcintyre, P.J.,Atrash, B.,Kosmopoulou, M.,O'Fee, L.,Burke, R.,Sun, C.,Faisal, A.,Bush, K.,Avery, S.,Henley, A.,Raynaud, F.I.,Linardopoulos, S.,Bayliss, R.,Blagg, J. 7-(Pyrazol-4-Yl)-3H-Imidazo[4,5-B]Pyridine-Based Derivatives for Kinase Inhibition: Co-Crystallisation Studies with Aurora-A Reveal Distinct Differences in the Orientation of the Pyrazole N1-Substituent. Bioorg.Med.Chem.Lett., 25:4203-, 2015 Cited by PubMed: 26296477 DOI: 10.1016/J.BMCL.2015.08.003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.78 Å)

Structure validation