5A97

Hazara virus nucleocapsid protain

5A97 の概要

• エントリーDOI: 10.2210/pdb5a97/pdb
• 分子名称: NUCLEOCAPSID PROTEIN (2 entities in total)
• 機能のキーワード: viral protein, hazara, nucleocapsid
• 由来する生物種: HAZARA VIRUS
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 218568.55

構造登録者

Surtees, R.,Ariza, A.,Hewson, R.,Barr, J.N.,Edwards, T.A. (登録日: 2015-07-17, 公開日: 2016-01-13, 最終更新日: 2024-01-10)

主引用文献

Surtees, R.,Ariza, A.,Punch, E.K.,Trinh, C.H.,Dowall, S.D.,Hewson, R.,Hiscox, J.A.,Barr, J.N.,Edwards, T.A.
The Crystal Structure of the Hazara Virus Nucleocapsid Protein.
Bmc Struct.Biol., 15:24-, 2015

PubMed Abstract: Hazara virus (HAZV) is a member of the Bunyaviridae family of segmented negative stranded RNA viruses, and shares the same serogroup as Crimean-Congo haemorrhagic fever virus (CCHFV). CCHFV is responsible for fatal human disease with a mortality rate approaching 30 %, which has an increased recent incidence within southern Europe. There are no preventative or therapeutic treatments for CCHFV-mediated disease, and thus CCHFV is classified as a hazard group 4 pathogen. In contrast HAZV is not associated with serious human disease, although infection of interferon receptor knockout mice with either CCHFV or HAZV results in similar disease progression. To characterise further similarities between HAZV and CCHFV, and support the use of HAZV as a model for CCHFV infection, we investigated the structure of the HAZV nucleocapsid protein (N) and compared it to CCHFV N. N performs an essential role in the viral life cycle by encapsidating the viral RNA genome, and thus, N represents a potential therapeutic target.

PubMed: 26715309
DOI: 10.1186/S12900-015-0051-3

実験手法

X-RAY DIFFRACTION (2.7 Å)