5A8Y

Crystal Structure of human neutrophil elastase in complex with a dihydropyrimidone inhibitor

5A8Y の概要

• エントリーDOI: 10.2210/pdb5a8y/pdb
• 関連するPDBエントリー: 5A8X 5A8Z
• 分子名称: NEUTROPHIL ELASTASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: trypsin family fold, protease, hydrolase, hydrolase-inhibitor complex
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25033.57

構造登録者

vonNussbaum, F.,Li, V.M.,Meibom, D.,Anlauf, S.,Bechem, M.,Delbeck, M.,Gerisch, M.,Harrenga, A.,Karthaus, D.,Lang, D.,Lustig, K.,Mittendorf, J.,Schaefer, M.,Schaefer, S.,Schamberger, J. (登録日: 2015-07-17, 公開日: 2016-08-03, 最終更新日: 2020-07-29)

• 主引用文献: Von Nussbaum, F.,Li, V.M.,Meibom, D.,Anlauf, S.,Bechem, M.,Delbeck, M.,Gerisch, M.,Harrenga, A.,Karthaus, D.,Lang, D.,Lustig, K.,Mittendorf, J.,Schafer, M.,Schafer, S.,Schamberger, J.; Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: In Vivo Efficacy of the Polar Pyrimidopyridazine Bay-8040 in a Pulmonary Arterial Hypertension Rat Model.; Chemmedchem, 11:199-, 2016; PubMed: 26333652; DOI: 10.1002/CMDC.201500269

実験手法

X-RAY DIFFRACTION (1.9 Å)