5A7O

Crystal structure of human JMJD2A in complex with compound 42

Summary for 5A7O

Entry DOI	10.2210/pdb5a7o/pdb
Related	5A7N 5A7P 5A7Q 5A7S
Descriptor	LYSINE-SPECIFIC DEMETHYLASE 4A, SULFATE ION, 2-[5-(2-methoxyethanoylamino)-2-oxidanyl-phenyl]pyridine-4-carboxylic acid, ... (8 entities in total)
Functional Keywords	oxidoreductase, jmjd2a, kdm4a
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus : O75164
Total number of polymer chains	2
Total formula weight	90871.20
Authors	Nowak, R.,Velupillai, S.,Krojer, T.,Gileadi, C.,Johansson, C.,Korczynska, M.,Le, D.D.,Younger, N.,Gregori-Puigjane, E.,Tumber, A.,Iwasa, E.,Pollock, S.B.,Ortiz Torres, I.,Pinkas, D.M.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.,Shoichet, B.K.,Fujimori, D.G.,Oppermann, U. (deposition date: 2015-07-09, release date: 2016-01-13, Last modification date: 2024-01-10)
Primary citation	Korczynska, M.,Le, D.D.,Younger, N.,Gregori-Puigjane, E.,Tumber, A.,Krojer, T.,Velupillai, S.,Gileadi, C.,Nowak, R.P.,Iwasa, E.,Pollock, S.B.,Ortiz Torres, I.,Oppermann, U.,Shoichet, B.K.,Fujimori, D.G. Docking and Linking of Fragments to Discover Jumonji Histone Demethylase Inhibitors. J.Med.Chem., 59:1580-, 2016 Cited by PubMed: 26699912 DOI: 10.1021/ACS.JMEDCHEM.5B01527 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation