5A5W

Crystal structure of Salmonella enterica HisA D7N D176A with ProFAR

5A5W の概要

• エントリーDOI: 10.2210/pdb5a5w/pdb
• 分子名称: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase, [(2R,3S,4R,5R)-5-[4-aminocarbonyl-5-[(E)-[[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]amino]methylideneamino]imidazol-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl dihydrogen phosphate (3 entities in total)
• 機能のキーワード: isomerase, histidine biosynthesis, profar
• 由来する生物種: Salmonella enterica
• 細胞内の位置: Cytoplasm: A0A630AQ07
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27664.26

構造登録者

Soderholm, A.,Guo, X.,Newton, M.S.,Evans, G.B.,Nasvall, J.,Patrick, W.M.,Selmer, M. (登録日: 2015-06-23, 公開日: 2015-09-02, 最終更新日: 2024-01-10)

• 主引用文献: Soderholm, A.,Guo, X.,Newton, M.S.,Evans, G.B.,Nasvall, J.,Patrick, W.M.,Selmer, M.; Two-Step Ligand Binding in a Beta/Alpha8 Barrel Enzyme -Substrate-Bound Structures Shed New Light on the Catalytic Cycle of Hisa; J.Biol.Chem., 290:24657-, 2015; PubMed: 26294764; DOI: 10.1074/JBC.M115.678086

実験手法

X-RAY DIFFRACTION (1.6 Å)