5A3T

Crystal structure of human PLU-1 (JARID1B) in complex with KDM5-C49 (2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl) isonicotinic acid).

5A3T の概要

• エントリーDOI: 10.2210/pdb5a3t/pdb
• 関連するPDBエントリー: 5A3N 5A3W
• 分子名称: LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (8 entities in total)
• 機能のキーワード: oxidoreductase, lysine-specific demethylase 5b
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus : Q9UGL1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 56615.76

構造登録者

Srikannathasan, V.,Johansson, C.,Gileadi, C.,Kopec, J.,Strain-Damerell, C.,Kupinska, K.,BurgessBrown, N.A.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.M.,Oppermann, U. (登録日: 2015-06-02, 公開日: 2015-06-17, 最終更新日: 2016-06-29)

• 主引用文献: Johansson, C.,Velupillai, S.,Tumber, A.,Szykowska, A.,Hookway, E.S.,Nowak, R.P.,Strain-Damerell, C.,Gileadi, C.,Philpott, M.,Burgess-Brown, N.,Wu, N.,Kopec, J.,Nuzzi, A.,Steuber, H.,Egner, U.,Badock, V.,Munro, S.,Lathangue, N.B.,Westaway, S.,Brown, J.,Athanasou, N.,Prinjha, R.,Brennan, P.E.,Oppermann, U.; Structural Analysis of Human Kdm5B Guides Histone Demethylase Inhibitor Development.; Nat.Chem.Biol., 12:539-, 2016; PubMed: 27214403; DOI: 10.1038/NCHEMBIO.2087

実験手法

X-RAY DIFFRACTION (1.9 Å)