5A3N

Crystal structure of human PLU-1 (JARID1B) in complex with KDOAM25a

Summary for 5A3N

Entry DOI	10.2210/pdb5a3n/pdb
Descriptor	LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, MANGANESE (II) ION, ... (9 entities in total)
Functional Keywords	oxidoreductase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Nucleus : Q9UGL1
Total number of polymer chains	1
Total formula weight	56844.42
Authors	Srikannathasan, V.,Johansson, C.,Gileadi, C.,Nuzzi, A.,Ruda, G.F.,Kopec, J.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.,Brennan, P.,Oppermann, U. (deposition date: 2015-06-02, release date: 2015-07-08, Last modification date: 2017-03-29)
Primary citation	Tumber, A.,Nuzzi, A.,Hookway, E.S.,Hatch, S.B.,Velupillai, S.,Johansson, C.,Kawamura, A.,Savitsky, P.,Yapp, C.,Szykowska, A.,Wu, N.,Bountra, C.,Strain-Damerell, C.,Burgess-Brown, N.A.,Ruda, G.F.,Fedorov, O.,Munro, S.,England, K.S.,Nowak, R.P.,Schofield, C.J.,La Thangue, N.B.,Pawlyn, C.,Davies, F.,Morgan, G.,Athanasou, N.,Muller, S.,Oppermann, U.,Brennan, P.E. Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. Cell Chem Biol, 24:371-380, 2017 Cited by PubMed: 28262558 DOI: 10.1016/j.chembiol.2017.02.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation