5A3N

Crystal structure of human PLU-1 (JARID1B) in complex with KDOAM25a

5A3N の概要

• エントリーDOI: 10.2210/pdb5a3n/pdb
• 分子名称: LYSINE-SPECIFIC DEMETHYLASE 5B, ZINC ION, MANGANESE (II) ION, ... (9 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Nucleus : Q9UGL1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 56844.42

構造登録者

Srikannathasan, V.,Johansson, C.,Gileadi, C.,Nuzzi, A.,Ruda, G.F.,Kopec, J.,von Delft, F.,Arrowsmith, C.H.,Bountra, C.,Edwards, A.,Brennan, P.,Oppermann, U. (登録日: 2015-06-02, 公開日: 2015-07-08, 最終更新日: 2017-03-29)

• 主引用文献: Tumber, A.,Nuzzi, A.,Hookway, E.S.,Hatch, S.B.,Velupillai, S.,Johansson, C.,Kawamura, A.,Savitsky, P.,Yapp, C.,Szykowska, A.,Wu, N.,Bountra, C.,Strain-Damerell, C.,Burgess-Brown, N.A.,Ruda, G.F.,Fedorov, O.,Munro, S.,England, K.S.,Nowak, R.P.,Schofield, C.J.,La Thangue, N.B.,Pawlyn, C.,Davies, F.,Morgan, G.,Athanasou, N.,Muller, S.,Oppermann, U.,Brennan, P.E.; Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.; Cell Chem Biol, 24:371-380, 2017; PubMed: 28262558; DOI: 10.1016/j.chembiol.2017.02.006

実験手法

X-RAY DIFFRACTION (2 Å)