5YVE

Crystal structure of human P2X3 receptor in complex with the AF-219 negative allosteric modulator

Summary for 5YVE

Entry DOI	10.2210/pdb5yve/pdb
Descriptor	P2X purinoceptor 3, MAGNESIUM ION, SODIUM ION, ... (5 entities in total)
Functional Keywords	ion channels, atp, transport protein
Biological source	Homo sapiens (Human)
Cellular location	Membrane; Multi-pass membrane protein: P56373
Total number of polymer chains	1
Total formula weight	41737.19
Authors	Wang, Y.,Hattori, M. (deposition date: 2017-11-25, release date: 2018-04-04, Last modification date: 2020-07-29)
Primary citation	Wang, J.,Wang, Y.,Cui, W.W.,Huang, Y.,Yang, Y.,Liu, Y.,Zhao, W.S.,Cheng, X.Y.,Sun, W.S.,Cao, P.,Zhu, M.X.,Wang, R.,Hattori, M.,Yu, Y. Druggable negative allosteric site of P2X3 receptors. Proc. Natl. Acad. Sci. U.S.A., 115:4939-4944, 2018 Cited by PubMed: 29674445 DOI: 10.1073/pnas.1800907115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation