5YVE
Crystal structure of human P2X3 receptor in complex with the AF-219 negative allosteric modulator
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001614 | molecular_function | purinergic nucleotide receptor activity |
| A | 0004931 | molecular_function | extracellularly ATP-gated monoatomic cation channel activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0007165 | biological_process | signal transduction |
| A | 0010524 | biological_process | positive regulation of calcium ion transport into cytosol |
| A | 0016020 | cellular_component | membrane |
| A | 0030424 | cellular_component | axon |
| A | 0033198 | biological_process | response to ATP |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0035590 | biological_process | purinergic nucleotide receptor signaling pathway |
| A | 0043005 | cellular_component | neuron projection |
| A | 0043235 | cellular_component | receptor complex |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050804 | biological_process | modulation of chemical synaptic transmission |
| A | 0050850 | biological_process | positive regulation of calcium-mediated signaling |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0060079 | biological_process | excitatory postsynaptic potential |
| A | 0070207 | biological_process | protein homotrimerization |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0071318 | biological_process | cellular response to ATP |
| A | 0098655 | biological_process | monoatomic cation transmembrane transport |
| A | 0098685 | cellular_component | Schaffer collateral - CA1 synapse |
| A | 0098686 | cellular_component | hippocampal mossy fiber to CA3 synapse |
| A | 0098794 | cellular_component | postsynapse |
Functional Information from PROSITE/UniProt
| site_id | PS01212 |
| Number of Residues | 27 |
| Details | P2X_RECEPTOR ATP P2X receptors signature. GGvLGIkIgWvCDLDkawdqCiPkYsF |
| Chain | Residue | Details |
| A | GLY236-PHE262 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 278 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29674445","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5YVE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29674445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31232692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SVS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"5SVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29674445","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31232692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YVE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"27626375","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31232692","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5SVJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5SVT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6AH5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
