5YT2
Crystal structure of the human vitamin D receptor ligand binding domain complexed with (1R,2S,3R)-5-[(E)-2-{(1R,3aS,7aR)-1-[(R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,6,7,7a-hexahydro-1H-inden-4-yl}vinyl]-2-(3-hydroxypropyl)cyclohex-4-ene-1,3-diol
Summary for 5YT2
Entry DOI | 10.2210/pdb5yt2/pdb |
Descriptor | Vitamin D3 receptor, (1R,2S,3R)-5-[(E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methyl-6-oxidanyl-heptan-2-yl]-1,2,3,3a,6,7-hexahydroinden-4-yl]ethenyl]-2-(3-oxidanylpropyl)cyclohex-4-ene-1,3-diol (3 entities in total) |
Functional Keywords | active ligand, complex, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : P11473 |
Total number of polymer chains | 1 |
Total formula weight | 29409.11 |
Authors | Takimoto-Kamimura, M.,Kakuda, S. (deposition date: 2017-11-16, release date: 2018-04-11, Last modification date: 2023-11-22) |
Primary citation | Sawada, D.,Kakuda, S.,Takeuchi, A.,Kawagoe, F.,Takimoto-Kamimura, M.,Kittaka, A. Effects of 2-substitution on 14-epi-19-nortachysterol-mediated biological events: based on synthesis and X-ray co-crystallographic analysis with the human vitamin D receptor. Org. Biomol. Chem., 16:2448-2455, 2018 Cited by PubMed: 29560490DOI: 10.1039/C8OB00158H PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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