5YQX
Crystal Structure Analysis of the BRD4
Summary for 5YQX
Entry DOI | 10.2210/pdb5yqx/pdb |
Descriptor | Bromodomain-containing protein 4, (2R)-2-(cyclopropylmethyl)-7-(3,5-dimethyl-1,2-oxazol-4-yl)-4H-1,4-benzoxazin-3-one, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | bet, brd4, bromodomain, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 17090.71 |
Authors | |
Primary citation | Xue, X.,Zhang, Y.,Wang, C.,Zhang, M.,Xiang, Q.,Wang, J.,Wang, A.,Li, C.,Zhang, C.,Zou, L.,Wang, R.,Wu, S.,Lu, Y.,Chen, H.,Ding, K.,Li, G.,Xu, Y. Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer. Eur.J.Med.Chem., 152:542-559, 2018 Cited by PubMed: 29758518DOI: 10.1016/j.ejmech.2018.04.034 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.82 Å) |
Structure validation
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