5YC5
Crystal structure of human IgG-Fc in complex with aglycan and optimized Fc gamma receptor IIIa
Summary for 5YC5
Entry DOI | 10.2210/pdb5yc5/pdb |
Descriptor | Immunoglobulin gamma-1 heavy chain, Low affinity immunoglobulin gamma Fc region receptor III-A, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
Functional Keywords | immunoglobulin g; fc receptor; affinity chromatography; protein glycosylation; calorimetry; protein dynamics, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 74064.12 |
Authors | Caaveiro, J.M.M.,Tamura, H.,Tsumoto, K.,Kiyoshi, M. (deposition date: 2017-09-06, release date: 2018-03-21, Last modification date: 2023-11-22) |
Primary citation | Kiyoshi, M.,Caaveiro, J.M.M.,Tada, M.,Tamura, H.,Tanaka, T.,Terao, Y.,Morante, K.,Harazono, A.,Hashii, N.,Shibata, H.,Kuroda, D.,Nagatoishi, S.,Oe, S.,Ide, T.,Tsumoto, K.,Ishii-Watabe, A. Assessing the Heterogeneity of the Fc-Glycan of a Therapeutic Antibody Using an engineered Fc gamma Receptor IIIa-Immobilized Column. Sci Rep, 8:3955-3955, 2018 Cited by PubMed: 29500371DOI: 10.1038/s41598-018-22199-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.71 Å) |
Structure validation
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