5YC5
Crystal structure of human IgG-Fc in complex with aglycan and optimized Fc gamma receptor IIIa
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Immunoglobulin gamma-1 heavy chain | polymer | 223 | 25106.4 | 2 | UniProt (P0DOX5) Pfam (PF07654) | Homo sapiens (Human) | Immunoglobulin gamma-1 heavy chain NIE |
| 2 | C (C) | Low affinity immunoglobulin gamma Fc region receptor III-A | polymer | 182 | 20727.0 | 1 | UniProt (P08637) Pfam (PF13895) | Homo sapiens (Human) | CD16a antigen,Fc-gamma RIII-alpha,FcRIIIa,FcR-10,IgG Fc receptor III-2 |
| 3 | D (D) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1625.5 | 1 | In PDB GlyTouCan (G27919IH) | |||
| 4 | E (E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1463.3 | 1 | In PDB GlyTouCan (G80858MF) | |||
| 5 | F (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | G, H, I (A, B, C) | water | water | 18.0 | 35 | Chemie (HOH) |
Sequence modifications
C: 1 - 175 (UniProt: P08637)
| PDB | External Database | Details |
|---|---|---|
| Glu 9 | Val 27 | engineered mutation |
| Ile 11 | Phe 29 | engineered mutation |
| Asn 17 | Tyr 35 | engineered mutation |
| Arg 30 | Gln 48 | engineered mutation |
| Leu 57 | Phe 75 | engineered mutation |
| Ser 74 | Asn 92 | engineered mutation |
| Glu 99 | Val 117 | engineered mutation |
| Gly 103 | Glu 121 | engineered mutation |
| Ser 153 | Phe 171 | engineered mutation |
| Val 158 | Phe 176 | variant |
| Gly 176 | - | expression tag |
| His 177 | - | expression tag |
| His 178 | - | expression tag |
| His 179 | - | expression tag |
| His 180 | - | expression tag |
| His 181 | - | expression tag |
| His 182 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 70939.8 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 3088.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 35.5 | |
| All* | Total formula weight | 74064.1 |
