5Y93
Crystal Structure Analysis of the BRD4
Summary for 5Y93
Entry DOI | 10.2210/pdb5y93/pdb |
Descriptor | Bromodomain-containing protein 4, 2-[[5-[(5-bromanyl-2-methoxy-phenyl)sulfonylamino]-3-methyl-1,2-benzoxazol-6-yl]oxy]-N-(2-morpholin-4-ylethyl)ethanamide, NITRATE ION, ... (6 entities in total) |
Functional Keywords | brd4(1), bromodomain, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 17721.04 |
Authors | |
Primary citation | Zhang, M.,Zhang, Y.,Song, M.,Xue, X.,Wang, J.,Wang, C.,Zhang, C.,Li, C.,Xiang, Q.,Zou, L.,Wu, X.,Wu, C.,Dong, B.,Xue, W.,Zhou, Y.,Chen, H.,Wu, D.,Ding, K.,Xu, Y. Structure-Based Discovery and Optimization of Benzo[ d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC) J. Med. Chem., 61:3037-3058, 2018 Cited by PubMed: 29566488DOI: 10.1021/acs.jmedchem.8b00103 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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