5XQX
Human CDK8-CYCC in complex with compound 4: N-methyl-4-(4-pyridyl)-1H-pyrrole-2-carboxamide
Summary for 5XQX
Entry DOI | 10.2210/pdb5xqx/pdb |
Descriptor | Cyclin-dependent kinase 8, Cyclin-C, GLYCEROL, ... (5 entities in total) |
Functional Keywords | cdk8, cyclin c, mediator complex, transferase |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : P49336 P24863 |
Total number of polymer chains | 2 |
Total formula weight | 75868.18 |
Authors | |
Primary citation | Han, X.,Jiang, M.,Zhou, C.,Zhou, Z.,Xu, Z.,Wang, L.,Mayweg, A.V.,Niu, R.,Jin, T.G.,Yang, S. Discovery of potent and selective CDK8 inhibitors through FBDD approach Bioorg. Med. Chem. Lett., 27:4488-4492, 2017 Cited by PubMed: 28802632DOI: 10.1016/j.bmcl.2017.07.080 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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