5XQX
Human CDK8-CYCC in complex with compound 4: N-methyl-4-(4-pyridyl)-1H-pyrrole-2-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Cyclin-dependent kinase 8 | polymer | 380 | 44273.1 | 1 | UniProt (P49336) Pfam (PF00069) In PDB | Homo sapiens (Human) | Cell division protein kinase 8,Mediator complex subunit CDK8,Mediator of RNA polymerase II transcription subunit CDK8,Protein kinase K35 |
| 2 | B | Cyclin-C | polymer | 263 | 31209.7 | 1 | UniProt (P24863) Pfam (PF00134) Pfam (PF16899) In PDB | Homo sapiens (Human) | SRB11 homolog,hSRB11 |
| 3 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 4 | A | N-methyl-4-pyridin-4-yl-1H-pyrrole-2-carboxamide | non-polymer | 201.2 | 1 | Chemie (8CC) | |||
| 5 | water | water | 18.0 | 178 | Chemie (HOH) |
Sequence modifications
A: 1 - 371 (UniProt: P49336)
| PDB | External Database | Details |
|---|---|---|
| Gly -8 | - | expression tag |
| Ala -7 | - | expression tag |
| Met -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Ser -4 | - | expression tag |
| His -3 | - | expression tag |
| Met -2 | - | expression tag |
| Glu -1 | - | expression tag |
| Phe 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75482.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 385.4 | |
| All* | Total formula weight | 75868.2 |
