5XPI
Structure of UHRF1 TTD in complex with NV01
Summary for 5XPI
Entry DOI | 10.2210/pdb5xpi/pdb |
Descriptor | E3 ubiquitin-protein ligase UHRF1, N-[3-(diethylamino)propyl]-2-(12-methyl-9-oxidanylidene-5-thia-1,10,11-triazatricyclo[6.4.0.0^2,6]dodeca-2(6),3,7,11-tetraen-10-yl)ethanamide (3 entities in total) |
Functional Keywords | ttd domain, small molecule, ligase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 18825.04 |
Authors | |
Primary citation | Senisterra, G.,Zhu, H.Y.,Luo, X.,Zhang, H.,Xun, G.,Lu, C.,Xiao, W.,Hajian, T.,Loppnau, P.,Chau, I.,Li, F.,Allali-Hassani, A.,Atadja, P.,Oyang, C.,Li, E.,Brown, P.J.,Arrowsmith, C.H.,Zhao, K.,Yu, Z.,Vedadi, M. Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain SLAS Discov, 23:930-940, 2018 Cited by PubMed: 29562800DOI: 10.1177/2472555218766278 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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