5X5O
Crystal structure of ZAK in complex with compound D2829
Summary for 5X5O
Entry DOI | 10.2210/pdb5x5o/pdb |
Descriptor | Mitogen-activated protein kinase kinase kinase MLT, N-[2,4-bis(fluoranyl)-3-[2-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]phenyl]-3-bromanyl-benzenesulfonamide (3 entities in total) |
Functional Keywords | zak, kinase, inhibitor, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q9NYL2 |
Total number of polymer chains | 1 |
Total formula weight | 35856.82 |
Authors | |
Primary citation | Chang, Y.,Lu, X.,Shibu, M.A.,Dai, Y.B.,Luo, J.,Zhang, Y.,Li, Y.,Zhao, P.,Zhang, Z.,Xu, Y.,Tu, Z.C.,Zhang, Q.W.,Yun, C.H.,Huang, C.Y.,Ding, K. Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors. J. Med. Chem., 60:5927-5932, 2017 Cited by PubMed: 28586211DOI: 10.1021/acs.jmedchem.7b00572 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.868 Å) |
Structure validation
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