5WRQ
Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor
Summary for 5WRQ
Entry DOI | 10.2210/pdb5wrq/pdb |
Related | 5WRY 5WRZ 5WS0 5WS1 |
Descriptor | Poly [ADP-ribose] polymerase 1, 5-[[2,4-bis(oxidanylidene)quinazolin-1-yl]methyl]-2-fluoranyl-N-[(3R)-1-(3-methylbutyl)pyrrolidin-3-yl]benzamide (2 entities in total) |
Functional Keywords | inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: P09874 |
Total number of polymer chains | 2 |
Total formula weight | 79781.34 |
Authors | Cao, R.,Wang, Y.L.,Zhou, J.,Huang, N.,Xu, B.L. (deposition date: 2016-12-03, release date: 2017-01-25, Last modification date: 2024-03-20) |
Primary citation | Cao, R.,Wang, Y.L.,Zhou, J.,Huang, N.,Xu, B.L. Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
Download full validation report