5WGC
propionyl-DpsC in complex with oxetane-bearing probe
Summary for 5WGC
Entry DOI | 10.2210/pdb5wgc/pdb |
Descriptor | Daunorubicin-doxorubicin polyketide synthase, (3-{[2-({N-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]sulfanyl}oxetan-3-yl)acetic acid (3 entities in total) |
Functional Keywords | enzyme-probe complex, transferase |
Biological source | Streptomyces peucetius |
Total number of polymer chains | 2 |
Total formula weight | 76139.81 |
Authors | Milligan, J.C.,Ellis, B.D.,White, A.R.,Vanderwal, C.D.,Tsai, S.C. (deposition date: 2017-07-13, release date: 2018-04-18, Last modification date: 2023-11-15) |
Primary citation | Ellis, B.D.,Milligan, J.C.,White, A.R.,Duong, V.,Altman, P.X.,Mohammed, L.Y.,Crump, M.P.,Crosby, J.,Luo, R.,Vanderwal, C.D.,Tsai, S.C. An Oxetane-Based Polyketide Surrogate To Probe Substrate Binding in a Polyketide Synthase. J. Am. Chem. Soc., 140:4961-4964, 2018 Cited by PubMed: 29620883DOI: 10.1021/jacs.7b11793 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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