5WBE
COX-1:MOFEZOLAC COMPLEX STRUCTURE
Summary for 5WBE
Entry DOI | 10.2210/pdb5wbe/pdb |
Related | 5U6X |
Descriptor | Prostaglandin G/H synthase 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | cox-1, cyclooxygenase, peroxidase, prostaglandin, heme, mofezolac, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Ovis aries (Sheep) |
Total number of polymer chains | 2 |
Total formula weight | 144186.36 |
Authors | Cingolani, G.,Panella, A.,Perrone, M.G.,Vitale, P.,Smith, W.L.,Scilimati, A. (deposition date: 2017-06-28, release date: 2017-07-26, Last modification date: 2023-10-04) |
Primary citation | Cingolani, G.,Panella, A.,Perrone, M.G.,Vitale, P.,Di Mauro, G.,Fortuna, C.G.,Armen, R.S.,Ferorelli, S.,Smith, W.L.,Scilimati, A. Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6). Eur J Med Chem, 138:661-668, 2017 Cited by PubMed: 28710965DOI: 10.1016/j.ejmech.2017.06.045 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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