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5WA9

Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside D-Ala phosphoramidate substrate complex

Summary for 5WA9
Entry DOI10.2210/pdb5wa9/pdb
Related3TW2 5IPB 5IPC 5KMA 5KMB
DescriptorHistidine triad nucleotide-binding protein 1, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[(2~{R})-1-methoxy-1-oxidanylidene-propan-2-yl]phosphonamidic acid, CHLORIDE ION, ... (4 entities in total)
Functional Keywordshistidine triad, hydrolase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm: P49773
Total number of polymer chains2
Total formula weight28612.07
Authors
Maize, K.M.,Finzel, B.C. (deposition date: 2017-06-26, release date: 2017-10-18, Last modification date: 2023-10-04)
Primary citationMaize, K.M.,Shah, R.,Strom, A.,Kumarapperuma, S.,Zhou, A.,Wagner, C.R.,Finzel, B.C.
A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides.
Mol. Pharm., 14:3987-3997, 2017
Cited by
PubMed: 28968488
DOI: 10.1021/acs.molpharmaceut.7b00664
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.15 Å)
Structure validation

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