5W4W
Identification and Profiling of a Selective and Brain Penetrant Radioligand for In Vivo Target Occupancy Measurement of Casein Kinase 1 (CK1) Inhibitors
Summary for 5W4W
Entry DOI | 10.2210/pdb5w4w/pdb |
Descriptor | Casein kinase I isoform delta, 4-[3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one, SULFATE ION, ... (4 entities in total) |
Functional Keywords | kinase, inhibitor, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: P48730 |
Total number of polymer chains | 4 |
Total formula weight | 156879.18 |
Authors | |
Primary citation | Wager, T.T.,Galatsis, P.,Chandrasekaran, R.Y.,Butler, T.W.,Li, J.,Zhang, L.,Mente, S.,Subramanyam, C.,Liu, S.,Doran, A.C.,Chang, C.,Fisher, K.,Grimwood, S.,Hedde, J.R.,Marconi, M.,Schildknegt, K. Identification and Profiling of a Selective and Brain Penetrant Radioligand for in Vivo Target Occupancy Measurement of Casein Kinase 1 (CK1) Inhibitors. ACS Chem Neurosci, 8:1995-2004, 2017 Cited by PubMed: 28609096DOI: 10.1021/acschemneuro.7b00155 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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