5VIO
Crystal structure of ASK1 kinase domain with a potent inhibitor (analog 13)
Summary for 5VIO
Entry DOI | 10.2210/pdb5vio/pdb |
Related | 5VIL |
Descriptor | Mitogen-activated protein kinase kinase kinase 5, 4-methoxy-N~1~-methyl-N~3~-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}benzene-1,3-dicarboxamide (3 entities in total) |
Functional Keywords | ask1, kinase drug discovery, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q99683 |
Total number of polymer chains | 4 |
Total formula weight | 133101.75 |
Authors | Jasti, J.,Chang, J.,Kurumbail, R. (deposition date: 2017-04-17, release date: 2018-01-17, Last modification date: 2024-03-06) |
Primary citation | Lovering, F.,Morgan, P.,Allais, C.,Aulabaugh, A.,Brodfuehrer, J.,Chang, J.,Coe, J.,Ding, W.,Dowty, H.,Fleming, M.,Frisbie, R.,Guzova, J.,Hepworth, D.,Jasti, J.,Kortum, S.,Kurumbail, R.,Mohan, S.,Papaioannou, N.,Strohbach, J.W.,Vincent, F.,Lee, K.,Zapf, C.W. Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors. Eur J Med Chem, 145:606-621, 2017 Cited by PubMed: 29348070DOI: 10.1016/j.ejmech.2017.12.041 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.84 Å) |
Structure validation
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