5VIO

Crystal structure of ASK1 kinase domain with a potent inhibitor (analog 13)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Mitogen-activated protein kinase kinase kinase 5	polymer	293	32979.6	4	UniProt (Q99683) Pfam (PF00069)	Homo sapiens (Human)	Apoptosis signal-regulating kinase 1,ASK-1,MAPK/ERK kinase kinase 5,MEKK 5
2	E, F, G (A, B, D)	4-methoxy-N~1~-methyl-N~3~-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}benzene-1,3-dicarboxamide	non-polymer		394.4	3	Chemie (9E4)
3	H, I, J, K (A, B, C, D)	water	water		18.0	204	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	131918.5
Non-Polymers*	Number of molecules	3
	Total formula weight	1183.3
All*	Total formula weight	133101.7

*Water molecules are not included.