5V61
Phospho-ERK2 bound to bivalent inhibitor SBP2
Summary for 5V61
Entry DOI | 10.2210/pdb5v61/pdb |
Related | 5V60 5V62 |
Descriptor | Mitogen-activated protein kinase 1, Ribosomal protein S6 kinase alpha-1,Protein Tat, GLYCEROL, ... (6 entities in total) |
Functional Keywords | kinase, mapk, phosphorylation, cancer, transferase-transferase inhibitor complex, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 45698.41 |
Authors | Lechtenberg, B.C.,Riedl, S.J. (deposition date: 2017-03-15, release date: 2017-07-26, Last modification date: 2023-11-15) |
Primary citation | Lechtenberg, B.C.,Mace, P.D.,Sessions, E.H.,Williamson, R.,Stalder, R.,Wallez, Y.,Roth, G.P.,Riedl, S.J.,Pasquale, E.B. Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors. ACS Med Chem Lett, 8:726-731, 2017 Cited by PubMed: 28740606DOI: 10.1021/acsmedchemlett.7b00127 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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