5V61

Phospho-ERK2 bound to bivalent inhibitor SBP2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Mitogen-activated protein kinase 1	polymer	356	41258.2	1	UniProt (P28482) Pfam (PF00069) In PDB	Homo sapiens (Human)	MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAPK 2
2	I	Ribosomal protein S6 kinase alpha-1,Protein Tat	polymer	28	3529.3	1	UniProt (Q15418) UniProt (P04608) In PDB	Homo sapiens	S6K-alpha-1,90 kDa ribosomal protein S6 kinase 1,p90S6K,MAP kinase-activated protein kinase 1a,MAPKAPK-1a,Ribosomal S6 kinase 1,RSK-1,Transactivating regulatory protein
3	A	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
4	I	5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE	non-polymer		327.3	1	Chemie (FRZ)
5	I	2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid	non-polymer		307.3	1	Chemie (90A)
6		water	water		18.0	92	Chemie (HOH)

Sequence modifications

A: 8 - 360 (UniProt: P28482)

PDB	External Database	Details
Gly 5	-	expression tag
Pro 6	-	expression tag
Gly 7	-	expression tag

I: 713 - 729 (UniProt: Q15418)

PDB	External Database	Details
Thr 711	-	expression tag
Ala 712	-	expression tag

I: 730 - 738 (UniProt: P04608)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	44787.4
Non-Polymers*	Number of molecules	5
	Total formula weight	911.0
All*	Total formula weight	45698.4

*Water molecules are not included.