5V61
Phospho-ERK2 bound to bivalent inhibitor SBP2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 1 | polymer | 356 | 41258.2 | 1 | UniProt (P28482) Pfam (PF00069) | Homo sapiens (Human) | MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAPK 2 |
| 2 | B (I) | Ribosomal protein S6 kinase alpha-1,Protein Tat | polymer | 28 | 3529.3 | 1 | UniProt (Q15418) UniProt (P04608) | Homo sapiens | S6K-alpha-1,90 kDa ribosomal protein S6 kinase 1,p90S6K,MAP kinase-activated protein kinase 1a,MAPKAPK-1a,Ribosomal S6 kinase 1,RSK-1,Transactivating regulatory protein |
| 3 | C, D, E (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | F (I) | 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE | non-polymer | 327.3 | 1 | Chemie (FRZ) | |||
| 5 | G (I) | 2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid | non-polymer | 307.3 | 1 | Chemie (90A) | |||
| 6 | H, I (A, I) | water | water | 18.0 | 92 | Chemie (HOH) |
Sequence modifications
A: 8 - 360 (UniProt: P28482)
I: 713 - 729 (UniProt: Q15418)
I: 730 - 738 (UniProt: P04608)
| PDB | External Database | Details |
|---|---|---|
| Gly 5 | - | expression tag |
| Pro 6 | - | expression tag |
| Gly 7 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Thr 711 | - | expression tag |
| Ala 712 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 44787.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 911.0 | |
| All* | Total formula weight | 45698.4 |
