5UUF

Bacillus cereus DNA glycosylase AlkD bound to a yatakemycin-adenine nucleobase adduct and DNA containing an abasic site (12-mer product complex)

Summary for 5UUF

• Entry DOI: 10.2210/pdb5uuf/pdb
• Related: 5UUG 5UUH 5UUJ
• Descriptor: DNA-7-methylguanine glycosylase, DNA (5'-D(*CP*CP*CP*CP*AP*(ORP)P*AP*GP*CP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*GP*CP*TP*TP*TP*GP*GP*GP*G)-3'), ... (5 entities in total)
• Functional Keywords: dna glycosylase, protein-dna complex, alkylpurine, bulky lesion, hydrolase-dna-antibiotic complex, hydrolase/dna/antibiotic
• Biological source: Bacillus cereus; More
• Total number of polymer chains: 3
• Total formula weight: 36603.53

Authors

Mullins, E.A.,Eichman, B.F. (deposition date: 2017-02-16, release date: 2017-07-19, Last modification date: 2023-10-04)

• Primary citation: Mullins, E.A.,Shi, R.,Eichman, B.F.; Toxicity and repair of DNA adducts produced by the natural product yatakemycin.; Nat. Chem. Biol., 13:1002-1008, 2017; PubMed: 28759018; DOI: 10.1038/nchembio.2439

Experimental method

X-RAY DIFFRACTION (1.612 Å)