5URC

Design, Synthesis, Functional and Biological Evaluation of Ether and Ester Derivatives of the Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease

Summary for 5URC

Entry DOI	10.2210/pdb5urc/pdb
Descriptor	Hemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ... (7 entities in total)
Functional Keywords	hemoglobin, antisickling, allosteric effector, aromatic aldehyde, oxygen transport
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	64953.35
Authors	Pagare, P.P.,Safo, R.S.,Gazi, A. (deposition date: 2017-02-10, release date: 2017-03-15, Last modification date: 2023-10-04)
Primary citation	Xu, G.G.,Pagare, P.P.,Ghatge, M.S.,Safo, R.P.,Gazi, A.,Chen, Q.,David, T.,Alabbas, A.B.,Musayev, F.N.,Venitz, J.,Zhang, Y.,Safo, M.K.,Abdulmalik, O. Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease. Mol. Pharm., 14:3499-3511, 2017 Cited by PubMed: 28858508 DOI: 10.1021/acs.molpharmaceut.7b00553 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation