5URC
Design, Synthesis, Functional and Biological Evaluation of Ether and Ester Derivatives of the Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease
Summary for 5URC
Entry DOI | 10.2210/pdb5urc/pdb |
Descriptor | Hemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ... (7 entities in total) |
Functional Keywords | hemoglobin, antisickling, allosteric effector, aromatic aldehyde, oxygen transport |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 64953.35 |
Authors | Pagare, P.P.,Safo, R.S.,Gazi, A. (deposition date: 2017-02-10, release date: 2017-03-15, Last modification date: 2023-10-04) |
Primary citation | Xu, G.G.,Pagare, P.P.,Ghatge, M.S.,Safo, R.P.,Gazi, A.,Chen, Q.,David, T.,Alabbas, A.B.,Musayev, F.N.,Venitz, J.,Zhang, Y.,Safo, M.K.,Abdulmalik, O. Design, Synthesis, and Biological Evaluation of Ester and Ether Derivatives of Antisickling Agent 5-HMF for the Treatment of Sickle Cell Disease. Mol. Pharm., 14:3499-3511, 2017 Cited by PubMed: 28858508DOI: 10.1021/acs.molpharmaceut.7b00553 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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