5UR1
FGFR1 kinase domain complex with SN37333 in reversible binding mode
Summary for 5UR1
Entry DOI | 10.2210/pdb5ur1/pdb |
Related | 5UOK 5UOL 5UOM 5UON |
Descriptor | Fibroblast growth factor receptor 1, 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{1-[4-(dimethylamino)but-2-enoyl]piperidin-4-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (3 entities in total) |
Functional Keywords | transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane; Single-pass type I membrane protein: P11362 |
Total number of polymer chains | 2 |
Total formula weight | 71988.35 |
Authors | Yosaatmadja, Y.,Paik, W.-K.,Smaill, J.B.,Squire, C.J. (deposition date: 2017-02-09, release date: 2017-05-31, Last modification date: 2023-10-04) |
Primary citation | Li, X.,Guise, C.P.,Taghipouran, R.,Yosaatmadja, Y.,Ashoorzadeh, A.,Paik, W.K.,Squire, C.J.,Jiang, S.,Luo, J.,Xu, Y.,Tu, Z.C.,Lu, X.,Ren, X.,Patterson, A.V.,Smaill, J.B.,Ding, K. 2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors. Eur J Med Chem, 135:531-543, 2017 Cited by PubMed: 28521156DOI: 10.1016/j.ejmech.2017.04.049 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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