5UR1
FGFR1 kinase domain complex with SN37333 in reversible binding mode
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Fibroblast growth factor receptor 1 | polymer | 311 | 35353.6 | 2 | UniProt (P11362) Pfam (PF07714) | Homo sapiens (Human) | FGFR-1,Basic fibroblast growth factor receptor 1,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr |
| 2 | C, D (A, B) | 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{1-[4-(dimethylamino)but-2-enoyl]piperidin-4-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one | non-polymer | 640.6 | 2 | Chemie (YY9) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 52 | Chemie (HOH) |
Sequence modifications
A, B: 459 - 765 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Gly 455 | - | expression tag |
| Ala 456 | - | expression tag |
| Met 457 | - | expression tag |
| Ser 458 | - | expression tag |
| Ala 488 | Cys 486 | engineered mutation |
| Ser 584 | Cys 582 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70707.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1281.1 | |
| All* | Total formula weight | 71988.3 |
