5UMC

Synthesis of novel seleno ureido containing compounds as SLC-0111 analogs. Investigations on carbonic anhydrases activity, glutathione peroxidase and X-ray crystallography

Summary for 5UMC

Entry DOI	10.2210/pdb5umc/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, GLYCEROL, ... (5 entities in total)
Functional Keywords	carbonic anhydrase inhibitors, metalloenzymes, glutathione peroxidase, lyase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29538.66
Authors	Peat, T.S.,Angeli, A.,Tanini, D.,Bartolucci, G.,Capperucci, A.,Supuran, C.T.,Carta, F. (deposition date: 2017-01-26, release date: 2017-12-06, Last modification date: 2023-10-04)
Primary citation	Angeli, A.,Tanini, D.,Peat, T.S.,Di Cesare Mannelli, L.,Bartolucci, G.,Capperucci, A.,Ghelardini, C.,Supuran, C.T.,Carta, F. Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors. ACS Med Chem Lett, 8:963-968, 2017 Cited by PubMed: 28947945 DOI: 10.1021/acsmedchemlett.7b00280 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation