Summary for 5UFP
Entry DOI | 10.2210/pdb5ufp/pdb |
Descriptor | Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, 3-({(1S)-7-[(difluoromethyl)sulfonyl]-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl}oxy)-5-fluorobenzonitrile, ... (4 entities in total) |
Functional Keywords | hif2 inhibitor hif2 ligand pas-b hypoxia inducible factor 2 epas1, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : Q99814 P27540 |
Total number of polymer chains | 2 |
Total formula weight | 27467.92 |
Authors | |
Primary citation | Cho, H.,Du, X.,Rizzi, J.P.,Liberzon, E.,Chakraborty, A.A.,Gao, W.,Carvo, I.,Signoretti, S.,Bruick, R.K.,Josey, J.A.,Wallace, E.M.,Kaelin, W.G. On-target efficacy of a HIF-2 alpha antagonist in preclinical kidney cancer models. Nature, 539:107-111, 2016 Cited by PubMed: 27595393DOI: 10.1038/nature19795 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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