Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Endothelial PAS domain-containing protein 1 | polymer | 115 | 13279.0 | 1 | UniProt (Q99814) Pfam (PF14598) | Homo sapiens (Human) | EPAS-1,Basic-helix-loop-helix-PAS protein MOP2,Class E basic helix-loop-helix protein 73,bHLHe73,HIF-1-alpha-like factor,HLF,Hypoxia-inducible factor 2-alpha,HIF2-alpha,Member of PAS protein 2,PAS domain-containing protein 2 |
| 2 | B (B) | Aryl hydrocarbon receptor nuclear translocator | polymer | 117 | 13769.6 | 1 | UniProt (P27540) Pfam (PF14598) | Homo sapiens (Human) | ARNT protein,Class E basic helix-loop-helix protein 2,bHLHe2,Dioxin receptor,nuclear translocator,Hypoxia-inducible factor 1-beta,HIF1-beta |
| 3 | C (A) | 3-({(1S)-7-[(difluoromethyl)sulfonyl]-2,2-difluoro-1-hydroxy-2,3-dihydro-1H-inden-4-yl}oxy)-5-fluorobenzonitrile | non-polymer | 419.3 | 1 | Chemie (86D) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 60 | Chemie (HOH) |
Sequence modifications
A: 239 - 348 (UniProt: Q99814)
B: 356 - 467 (UniProt: P27540)
| PDB | External Database | Details |
|---|---|---|
| Gly 234 | - | expression tag |
| Glu 235 | - | expression tag |
| Phe 236 | - | expression tag |
| Leu 237 | - | expression tag |
| Gly 238 | - | expression tag |
| Glu 247 | Arg 247 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 351 | - | expression tag |
| Glu 352 | - | expression tag |
| Phe 353 | - | expression tag |
| Leu 354 | - | expression tag |
| Gly 355 | - | expression tag |
| Arg 362 | Glu 348 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27048.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 419.3 | |
| All* | Total formula weight | 27467.9 |
