5UEG

RNA primer-template complex with guanosine dinucleotide G(5')pppp(5')G ligand

Summary for 5UEG

• Entry DOI: 10.2210/pdb5ueg/pdb
• Related: 5UED 5UEE 5UEF
• Descriptor: RNA (5'-R(*(LCC)P*(LCC)P*(LCC)P*GP*AP*CP*UP*UP*AP*AP*GP*UP*CP*G)-3'), [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [[[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl] hydrogen phosphate (2 entities in total)
• Functional Keywords: rna, dinucleotide
• Biological source: synthetic construct
• Total number of polymer chains: 4
• Total formula weight: 21476.72

Authors

Zhang, W.,Tam, C.P.,Szostak, J.W. (deposition date: 2017-01-02, release date: 2017-07-05, Last modification date: 2023-10-04)

• Primary citation: Zhang, W.,Tam, C.P.,Walton, T.,Fahrenbach, A.C.,Birrane, G.,Szostak, J.W.; Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex.; Proc. Natl. Acad. Sci. U.S.A., 114:7659-7664, 2017; PubMed: 28673998; DOI: 10.1073/pnas.1704006114

Experimental method

X-RAY DIFFRACTION (2.6 Å)