5TPG
Optimization of spirocyclic proline tryptophanhydroxylase-1 inhibitors
Summary for 5TPG
Entry DOI | 10.2210/pdb5tpg/pdb |
Related | 5L01 |
Descriptor | Tryptophan 5-hydroxylase 1, FE (III) ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (6 entities in total) |
Functional Keywords | tph1, iron, acyl, quanidine, oxidoreductase-inhibitor complex, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 36371.50 |
Authors | Stein, A.J.,Goldberg, D.R.,De Lombaert, S.,Holt, M.C. (deposition date: 2016-10-20, release date: 2017-01-25, Last modification date: 2024-03-06) |
Primary citation | Goldberg, D.R.,De Lombaert, S.,Aiello, R.,Bourassa, P.,Barucci, N.,Zhang, Q.,Paralkar, V.,Stein, A.J.,Holt, M.,Valentine, J.,Zavadoski, W. Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorg. Med. Chem. Lett., 27:413-419, 2017 Cited by PubMed: 28041831DOI: 10.1016/j.bmcl.2016.12.053 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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