5TE2
Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a mechanism-based inhibitor
Summary for 5TE2
Entry DOI | 10.2210/pdb5te2/pdb |
Related | 3TFT 3TFU 4CXQ |
Descriptor | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, [5-hydroxy-4-({[6-(3-hydroxypropyl)-4-oxo-1,4-dihydropyridin-3-yl]amino}methyl)-6-methylpyridin-3-yl]methyl dihydrogen phosphate, DI(HYDROXYETHYL)ETHER, ... (6 entities in total) |
Functional Keywords | inhibitor complex, transaminase, plp, transferase, transferase-inhibitor complex, mechanism-based inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) |
Total number of polymer chains | 2 |
Total formula weight | 98190.07 |
Authors | Maize, K.M.,Eiden, C.,Aldrich, C.C.,Finzel, B.C. (deposition date: 2016-09-20, release date: 2017-05-31, Last modification date: 2023-10-04) |
Primary citation | Eiden, C.G.,Maize, K.M.,Finzel, B.C.,Lipscomb, J.D.,Aldrich, C.C. Rational Optimization of Mechanism-Based Inhibitors through Determination of the Microscopic Rate Constants of Inactivation. J. Am. Chem. Soc., 139:7132-7135, 2017 Cited by PubMed: 28510452DOI: 10.1021/jacs.7b00962 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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