5SAV
DDR1, N-[2-[3-(2-aminopyrimidin-5-yl)oxyphenyl]ethyl]-3-(trifluoromethoxy)benzamide, 1.760A, P212121, Rfree=23.5%
Summary for 5SAV
Entry DOI | 10.2210/pdb5sav/pdb |
Group deposition | Novel Potent and Highly Selective DDR1 Inhibitors from Structure-guided Drug Design (G_1002213) |
Descriptor | Epithelial discoidin domain-containing receptor 1, N-(2-{3-[(2-aminopyrimidin-5-yl)oxy]phenyl}ethyl)-3-(trifluoromethoxy)benzamide, IODIDE ION, ... (4 entities in total) |
Functional Keywords | rtk, receptor tyrosine kinase, collagen, discoidin domain;, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 37301.94 |
Authors | Stihle, M.,Richter, H.,Benz, J.,Hochstrasser, R.,Rudolph, M.G. (deposition date: 2021-06-22, release date: 2022-06-29, Last modification date: 2024-04-03) |
Primary citation | Richter, H.,Prunotto, M.,Kuhn, B.,Rudolph, M.G. Crystal Structure of a DDR1 complex To be published, |
Experimental method | X-RAY DIFFRACTION (1.76 Å) |
Structure validation
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