5P8W
Crystal Structure of COMT in complex with [5-(2,4-dimethyl-1,3-thiazol-5-yl)-1H-pyrazol-3-yl]methanamine
Summary for 5P8W
Entry DOI | 10.2210/pdb5p8w/pdb |
Group deposition | Crystal Structure of COMT complex (G_1002007) |
Descriptor | Catechol O-methyltransferase, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, [5-(2,4-dimethyl-1,3-thiazol-5-yl)-1H-pyrazol-3-yl]methanamine, ... (6 entities in total) |
Functional Keywords | methyltransferase, neurotransmitter degradation, transferase |
Biological source | Rattus norvegicus (Rat) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734 |
Total number of polymer chains | 3 |
Total formula weight | 75423.62 |
Authors | Ehler, A.,Lerner, C.,Rudolph, M.G. (deposition date: 2016-08-25, release date: 2016-09-07, Last modification date: 2024-05-01) |
Primary citation | Lerner, C.,Rudolph, M.G. Crystal Structure of COMT complex To be published, |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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