5OR0

NMR derived model of the 5'-splice site of SMN2 in complex with the 5'-end of U1 snRNA

Summary for 5OR0

• Entry DOI: 10.2210/pdb5or0/pdb
• NMR Information: BMRB: 34171
• Descriptor: RNA (5'-R(P*AP*UP*AP*CP*(PSU)P*(PSU)P*AP*CP*CP*UP*G)-3'), RNA (5'-R(P*GP*GP*AP*GP*UP*AP*AP*GP*UP*CP*U)-3') (2 entities in total)
• Functional Keywords: 5'-splice site, smn2, small muscular atrophy, rna
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 6975.24

Authors

Campagne, S.,Clery, A.,Allain, F.H. (deposition date: 2017-08-14, release date: 2017-08-30, Last modification date: 2023-06-14)

• Primary citation: Sivaramakrishnan, M.,McCarthy, K.D.,Campagne, S.,Huber, S.,Meier, S.,Augustin, A.,Heckel, T.,Meistermann, H.,Hug, M.N.,Birrer, P.,Moursy, A.,Khawaja, S.,Schmucki, R.,Berntenis, N.,Giroud, N.,Golling, S.,Tzouros, M.,Banfai, B.,Duran-Pacheco, G.,Lamerz, J.,Hsiu Liu, Y.,Luebbers, T.,Ratni, H.,Ebeling, M.,Clery, A.,Paushkin, S.,Krainer, A.R.,Allain, F.H.,Metzger, F.; Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers.; Nat Commun, 8:1476-1476, 2017; PubMed: 29133793; DOI: 10.1038/s41467-017-01559-4

Experimental method

SOLUTION NMR