5OP6
Factor Inhibiting HIF (FIH) in complex with zinc and GSK128863
Summary for 5OP6
Entry DOI | 10.2210/pdb5op6/pdb |
Descriptor | Hypoxia-inducible factor 1-alpha inhibitor, ZINC ION, SULFATE ION, ... (6 entities in total) |
Functional Keywords | on-heme, dioxygenase, oxygenase, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, asparaginyl/aspartyl hydroxylase, epigenetic regulation, signaling, ard, beta-hydroxylation, activator-inhibitor, oxidoreductase-peptide complex, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: Q9NWT6 |
Total number of polymer chains | 1 |
Total formula weight | 41296.56 |
Authors | Leissing, T.M.,Schofield, C.J.,Clifton, I.J.,Thinnes, C.C.,Lu, X. (deposition date: 2017-08-09, release date: 2017-10-18, Last modification date: 2024-01-17) |
Primary citation | Yeh, T.L.,Leissing, T.M.,Abboud, M.I.,Thinnes, C.C.,Atasoylu, O.,Holt-Martyn, J.P.,Zhang, D.,Tumber, A.,Lippl, K.,Lohans, C.T.,Leung, I.K.H.,Morcrette, H.,Clifton, I.J.,Claridge, T.D.W.,Kawamura, A.,Flashman, E.,Lu, X.,Ratcliffe, P.J.,Chowdhury, R.,Pugh, C.W.,Schofield, C.J. Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials. Chem Sci, 8:7651-7668, 2017 Cited by PubMed: 29435217DOI: 10.1039/c7sc02103h PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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