5OCI
Human Heat Shock Protein 90 bound to 6-Hydroxy-3-(3-methyl-benzyl)-1H-indazole-5-carboxylic acid methyl-(4-morpholin-4-yl-phenyl)-amide
Summary for 5OCI
Entry DOI | 10.2210/pdb5oci/pdb |
Descriptor | Heat shock protein HSP 90-alpha, 6-Hydroxy-3-(3-methyl-benzyl)-1H-indazole-5-carboxylic acid methyl-(4-morpholin-4-yl-phenyl)-amide (3 entities in total) |
Functional Keywords | heat-shock protein complex, hsp90, atpase, pyrazole, chaperone, atp-binding, heat shock, nucleotide-binding, phosphorylation |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 26170.36 |
Authors | Schuetz, D.A.,Richter, L.,Amaral, M.,Grandits, M.,Musil, D.,Graedler, U.,Frech, M.,Ecker, G.F. (deposition date: 2017-07-03, release date: 2018-05-23, Last modification date: 2024-05-08) |
Primary citation | Schuetz, D.A.,Richter, L.,Amaral, M.,Grandits, M.,Gradler, U.,Musil, D.,Buchstaller, H.P.,Eggenweiler, H.M.,Frech, M.,Ecker, G.F. Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors. J. Med. Chem., 61:4397-4411, 2018 Cited by PubMed: 29701469DOI: 10.1021/acs.jmedchem.8b00080 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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