5OBR

Aurora A kinase in complex with 2-(3-chloro-5-fluorophenyl)quinoline-4-carboxylic acid and JNJ-7706621

Summary for 5OBR

Entry DOI	10.2210/pdb5obr/pdb
Descriptor	Aurora kinase A, 2-(3-chloranyl-5-fluoranyl-phenyl)quinoline-4-carboxylic acid, 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide, ... (5 entities in total)
Functional Keywords	inhibitor, kinase, allostery, protein-protein interface, cell cycle
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
Total number of polymer chains	1
Total formula weight	32176.51
Authors	Rossmann, M.,Janecek, M.,Hyvonen, M. (deposition date: 2017-06-29, release date: 2017-08-09, Last modification date: 2018-01-24)
Primary citation	Cole, D.J.,Janecek, M.,Stokes, J.E.,Rossmann, M.,Faver, J.C.,McKenzie, G.J.,Venkitaraman, A.R.,Hyvonen, M.,Spring, D.R.,Huggins, D.J.,Jorgensen, W.L. Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction. Chem. Commun. (Camb.), 53:9372-9375, 2017 Cited by PubMed: 28787041 DOI: 10.1039/c7cc05379g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.62 Å)

Structure validation