5OBR
Aurora A kinase in complex with 2-(3-chloro-5-fluorophenyl)quinoline-4-carboxylic acid and JNJ-7706621
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aurora kinase A | polymer | 272 | 31456.2 | 1 | UniProt (O14965) Pfam (PF00069) | Homo sapiens (Human) | Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A |
| 2 | B (A) | 2-(3-chloranyl-5-fluoranyl-phenyl)quinoline-4-carboxylic acid | non-polymer | 301.7 | 1 | Chemie (9QT) | |||
| 3 | C (A) | 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide | non-polymer | 394.4 | 1 | Chemie (SKE) | |||
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E (A) | water | water | 18.0 | 15 | Chemie (HOH) |
Sequence modifications
A: 125 - 391 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Gly 120 | - | expression tag |
| Ser 121 | - | expression tag |
| Met 122 | - | expression tag |
| Gly 123 | - | expression tag |
| Ser 124 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31456.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 720.4 | |
| All* | Total formula weight | 32176.5 |
