5OAX
Galectin-3c in complex with thiogalactoside derivate
Summary for 5OAX
Entry DOI | 10.2210/pdb5oax/pdb |
Related | 4BLI |
Descriptor | Galectin-3, 5,6-bis(fluoranyl)-3-[[(2~{S},3~{R},4~{S},5~{S},6~{R})-2-[(2~{S},3~{R},4~{S},5~{R},6~{R})-4-[4-(3-fluorophenyl)-1,2,3-triazol-1-yl]-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]sulfanyl-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-4-yl]oxymethyl]chromen-2-one (3 entities in total) |
Functional Keywords | sugar binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 16432.76 |
Authors | Nilsson, U.J.,Peterson, K.,Hakansson, M.,Logan, D.T. (deposition date: 2017-06-25, release date: 2018-05-02, Last modification date: 2024-05-08) |
Primary citation | Peterson, K.,Kumar, R.,Stenstrom, O.,Verma, P.,Verma, P.R.,Hakansson, M.,Kahl-Knutsson, B.,Zetterberg, F.,Leffler, H.,Akke, M.,Logan, D.T.,Nilsson, U.J. Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity. J. Med. Chem., 61:1164-1175, 2018 Cited by PubMed: 29284090DOI: 10.1021/acs.jmedchem.7b01626 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
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