5O3O
Pronase-treated paired helical filament in Alzheimer's disease brain
Summary for 5O3O
Entry DOI | 10.2210/pdb5o3o/pdb |
EMDB information | 3742 |
Descriptor | Microtubule-associated protein tau (1 entity in total) |
Functional Keywords | tau, amyloid, cross-beta, beta-helix, protein fibril |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm, cytosol : P10636 |
Total number of polymer chains | 10 |
Total formula weight | 79401.41 |
Authors | Fitzpatrick, A.W.P.,Falcon, B.,He, S.,Murzin, A.G.,Murshudov, G.,Garringer, H.G.,Crowther, R.A.,Ghetti, B.,Goedert, M.,Scheres, S.H.W. (deposition date: 2017-05-24, release date: 2017-07-26, Last modification date: 2024-05-15) |
Primary citation | Fitzpatrick, A.W.P.,Falcon, B.,He, S.,Murzin, A.G.,Murshudov, G.,Garringer, H.J.,Crowther, R.A.,Ghetti, B.,Goedert, M.,Scheres, S.H.W. Cryo-EM structures of tau filaments from Alzheimer's disease. Nature, 547:185-190, 2017 Cited by PubMed: 28678775DOI: 10.1038/nature23002 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.5 Å) |
Structure validation
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