5NXD

LIM Domain Kinase 2 (LIMK2) In Complex With TH-300

Summary for 5NXD

• Entry DOI: 10.2210/pdb5nxd/pdb
• Descriptor: LIM domain kinase 2, 4-[(3-chlorophenyl)sulfamoyl]-~{N}-(phenylmethyl)-~{N}-propyl-benzamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: kinase actin cytoskeleton inhibitor dfg-out, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Isoform LIMK2a: Cytoplasm. Isoform LIMK2b: Cytoplasm: P53671
• Total number of polymer chains: 2
• Total formula weight: 70609.47

Authors

Mathea, S.,Salah, E.,Hanke, T.,Newman, J.A.,Oerum, S.,Wang, D.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N.,Knapp, S. (deposition date: 2017-05-10, release date: 2017-05-24, Last modification date: 2024-01-17)

• Primary citation: Mathea, S.,Salah, E.,Hanke, T.,Newman, J.A.,Oerum, S.,Wang, D.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N.,Knapp, S.; LIM Domain Kinase 2 (LIMK2)In Complex With TH-300; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)